In Part 1, we explored the current thinking of conventional medicine’s’ approach to cancer, how it’s treated pharmaceutically using dangerous poisonous substances or simply just to cut or burn it out of the body.
These somewhat primitive treatments mimic the blood letting and mercury treatments that lasted 2000 years until the late 19th century.
Medicine uses these types of practice when they don’t understand the disease, despite the fact that the answers to cancer are hidden in the research. Seek and you will find.
Do you honestly believe that this highly intelligent.. Simplement un l’imitable chef d’oeuvre (Simply a masterpiece that cannot be equaled), organism like the human body would not have an answer to cancer. God is love not cruel.
The Origins of Chemotherapy
After World War I, there was a stockpile of nitrogen mustard gas that was used as a weapon to kill the fighting armies during the conflict.
During World War II, although the gas was not used, the Department of Defence (DOD) thought about how and where this surplus mustard gas could be used..
Then, in 1945 in an experimental research facility, some army personnel were exposed to this gas and died.
When they were autopsied the pathologist noticed that their white blood count had decreased and the bone marrow had been suppressed.
As a result one of the Department Of Defence (DOD) doctors had an idea, that maybe the nitrogen gas could be used to treat lymphoma and leukemia since they were both cancers derived from the bone marrow (the white cell line).
The DOD contracted 2 Yale University scientists, Louis Goodman and Alfred Gilman and asked them to conduct a study with animals who had cancerous growths, using a synthesized drug containing a nitrogen mustard gas derivative, which they did, and confirmed that the bone marrow had been ‘wiped out’ and the tumors regressed.
Although, a short time after, all the animals died, but this was the first time in history that cancer tumors had regressed from the use of a poisonous drug (synthesized in this case from the Nitrogen Mustard gas). At this point, in 1946 they decided to experiment with a human cancer patient suffering from advanced lymphoma of which there was no cure. It worked and the patients tumors also regressed, although within 6 weeks he was dead.
In the next 15 years they had manufactured a variety of synthetic drugs but all the chemotherapy drugs produced even the drugs used today, have their origins from the synthesis of deadly poisonous nitrogen mustard gas.
However, the initial excitement that somebody had found an ‘answer to cancer’ which of course was historic, waned because nobody was surviving. In the late 60’s the MOPP (Mustargen Oncovin Procarbazine Prednisone) an acronym for the 4 drug regimen treatment was put together by a Dr. Vincent Devita to treat Hodgkin’s lymphoma which was successful, since it increased survivability (or at least extended life) from 0-70% while working for the NCI.
It was pure coincidence that Devita had chosen a cancer cell line like Hodgkin’s lymphoma which is one of the few cancers that does respond to the highly poisonous chemotherapy treatment, destroying both the bone marrow and the.
However, in most if not all cases as we mentioned in Part 1, some of the cancer cells (the stem cells) are resistant to the toxic drugs and the cancer returns and a lot of the time more aggressively, which is also the case in Hodgkin’s lymphoma.
Routinely, these toxic drugs like Methotrexate affects the heart and liver. Avastin, which is a targeted drug, as we mentioned in part 1 interferes with bleeding which could be fatal. Even today, patients with blood derived cancers die because of the use of immunosuppressant drugs that shut down the immune system leaving the patient defenceless against dangerous pathogenes and in many cases expire from pneumonia.
We can all thank the great Madame Curie (1867-1934), physicist and chemist, for introducing the world to Radiation as a regimen to burn cancer out of the human body.
In and around 1896, 2 physicians in France and Chicago began using X-rays to treat cancer. Victor Despeignes used them on a patient with stomach cancer, but the results were inconclusive since the patient was receiving other treatments, but of course the patient died (not a big surprise).
The second physician, Emil Grubbe from Chicago used x-rays to treat breast cancer. Grubbe himself must have been a strong individual since he himself had 90 operations for recurrent cancer from the exposure to radiation, which he ultimately died from, but not before infecting..excuse me..instructing 7000 physicians on the medical use of x-rays.
At the same time, the use of X-rays to treat Lupus vulgaris (a Tuberculosis skin condition), by Leopold Freund an Austrian radiologist.
Then in 1900 a scientific feud erupted between Nikola Tesla, the Serbian physicist and Freund over what exactly was providing the therapeutic effect of the X-Ray treatment for these skin conditions. Tesla said it was the ozone (a gas that is produced from electrical discharge) and Freund said it was the X-ray itself, but by a medical societal vote it was the X-ray that killed..sorry healed, but who cares anyway, it was still highly toxic and people perished as a result.
You have to appreciate that these scientists were walking around carrying radium in their pockets, even in 1901 Henri Becquerel (French physicist and nobel prize winner for physics, the discoverer of radioactivity) walked around with a tube of radium in his pocket for a few hours, and then 2 weeks later he discovered a severe burn on his skin, but thought nothing of it, and did not realise the toxicity of this material (so much for the intellect of a Nobel Laureate).
Radium was now, however becoming popular, and it was at this point society ‘lost it’; manufacturers were putting radium in toothpaste, water dispensers, irradiated baths, radon inhalation rooms and radiation spas.
Then people started dying in 1915 and people were developing carcinomas (another surprise).
In the early days, Curies experimental materials included Pitchblende (a radioactive uranium rich mineral), Torbenite (a radioactive hydrated green copper uranium phosphate mineral) and Thorium (a radioactive actinide metal) carrying out her experiments in an badly ventilated, non waterproof shed that was converted from a schools dissection room, unaware of the induced damage she was being subjected to.
Madame Curie and her husband Pierre also both walked around with uranium in their pockets and they received a Nobel prize alongside Becquerel in Physics in 1903.
By 1934 she would be dead at the age of 66 from aplastic anemia contracted from the long term exposure of radiation (this is a testimonial to the wonderful human body that kept her alive so long after so much toxic poisoning she endured and her ignorance of how toxic radiation is, went with her to her grave ).
Henri Coutard a French radiologist developed a protracted, fractional process in 1934 to administer radiation sufficient enough to produce severe, but recoverable acute mucosal reaction, which remains the basis of radiation treatment today.
Typically, for example after a surgical removal of cancer, radiation is delivered immediately after, in some cases. And then maybe leeches are applied to the skin to really finish the job..lol.
The Origin of Cancer
Now that we have discussed the last 100 years of the modern ‘dark ages’ let us now ‘enter the light’. Before I do, and please bear with me because it’s relevant, I would like to explain early human reproduction, specifically the early development of the placenta.
Between 5-6 days after fertilization the original tiny ball of some 12-16 cells develop into an initial embryo referred to as a ‘Blastocyst’. This consists of a single layer of outer cells called ‘Trophoblast‘ cells, that are designed to invade the Endometrium of the Uterus, destined to be the Placenta, while the inner cells develop into the Embryo body.
In preparation of the uterine invasion, the trophoblast cells secrete enzymes to digest part of the ‘Zona Pellucida‘, the outer glycoprotein coating of the ‘Ovum’ or egg cell as a precursor activity before uterine implantation.
The uterus can only accept implantation between day 20 and 24 of the ovulatory cycle.
Cells within the endometrium secrete nutritive substances in preparation for implantation and cell surface receptors called ‘Integrins’ begin to grow and will act as ‘docking sites’ for the trophoblast cell complex.
Once the blastocyst makes contact with the uterus it is essential that it attaches to the endometrial epithelium quickly, to survive.
Once contact is established, the outer trophoblast layer of cells known as the Syncytiotrophoblast secrete more enzymes to break down the endometrial extracellular matrix preparing for blastocyst implantation.
Within 7-8 days the blastocyst has advanced further into the endometrium and signaling (autocrine) molecules secrete hormones such as Hormone Chorionic Gonadotropin (hCG). When hCG is released into the bloodstream, it stimulates the ovaries to release estrogen and progesterone that stimulate growth essential for implantation), and ‘Insulin-like Growth Factor’(IGF) allowing further invasive advancement.
To enhance implantation integrity, an anchor like structure is formed by the contact of ‘Apical epithelial protrusions’ (called ‘Pinopodes) that grow inside the uterine cavity that resemble microvilli ( projections not unlike the villi in the intestinal epithelium ).
During this period a choreography-like interfacing routine occurs between the Blastocyst and the uterus (Dr Gonzalez so eloquently refers to it as a ‘Molecular Ballet’ in his book ‘The Trophoblast and the Origins of Cancer’ ).
To initiate this 2 way communication the trophoblast synthesizes various growth factor signaling that includes the following:
- Leukemia Inhibitory Factor ( LIF ), an Interleukin 6 cytokine cell signaling substance that influences uterine acceptance, Decidualization ( endometrium cell conversion for pregnancy purposes ), blastocyt invasion and development, and immune modulation.
- Transforming growth factor alpha/beta ( a polypeptide -string of amino acids that is upregulated in human cancer and induces oncagene transformation
- Platelet derived growth factor ( a protein that regulates cell division/formation especially in ‘angiogenesis’ ( blood vessel formation) from an already existing blood supply
- Insulin-like growth factor II ( a protein that regulates both normal physiology ( normally released by the liver for early infant growth) but in this case fetal growth and pathology in cancer
- Colony Stimulating factor I ( Glycoprotein used for intracellular signaling pathway for cell proliferation and differentiation
- Interleukin 1 ( cytokine signaling to regulate immune and inflammatory response )
- Interleukin 6 ( Immune response stimulant that is also produced by T Cells and Macrophages that we came across in article ‘microbiome and the immune system )
By day 10-12, just like the ‘Starship enterprise’, docking is complete and implantation is complete.
How is this Possible?
There is however, one crucial point to consider. How does implantation of a ‘foreign’ growth survive the mother’s immune system. I have read in some text that the mother’s immune system is suppressed leaving her vulnerable to infection. This is a falsehood. I often state how intelligent the body is, and in its infinite design, logically this would never be allowed to happen.
All human mammalian cells contain a unique identifier ‘fingerprint’ which is expressed in the cell membrane in the form of an antigen protein referred to as ‘Major Histocompatibility Complex’ (MHC). It is this ID marker that is read by our immune system to distinguish self from invader. In autoimmune diseases that we have discussed in previous articles (Hashimoto’s disease, Psoriasis, etc) which is caused by microbiota imbalance, also inhibits the immune system cells to read the MHC ‘fingerprints.’
However, half of the cells are donated from the father that contain a different MHC fingerprint, so to overcome this the Trophoblast secrete messenger chemokines (Cytokine class signalling molecules used to signal white blood cells to come to an infection site) into the mother’s bloodstream.
These are not signals to ‘keep out’ immune system cells, but rather they are invitation signals inviting the immune cells to ‘join the implant party’.
These immune cells are not invited to fight pathogens, or clean up, they are invited for their tissue healing function, namely angiogenesis (form new blood vessels) critical for the survival of the embryo.
But the ‘foreign’ trophoblast (or at least half) is not ‘out of the woods yet’ so the trophoblast outwits the mother’s immune system by suppressing its own MHC Identifier thus avoiding an offensive immune system attack.
As a ‘backup’ defence, the Trophoblast secretes a number of immune modulating signals like Interleukin 10 which down regulates the expression of TH1, MHC antigens, stimulatory molecules from macrophages and blocks NF-kB ( Nuclear factor Kappa B which is a protein complex that regulates an inflammatory response ).
The Trophoblast also produces an enzyme that degrades ‘tryptophan’ that is essential for T-cell mobilization thus paralyzing their activity. (I know what you are thinking..’ain’t the body smart).
Isn’t this an article about Cancer?
Why have I explained fertilization and the beginning of life itself?
In the words of Sherlock Holmes “the game’s afoot Watson.”
The key is, that the activity, the signaling and the overall characteristics of the early placenta, the trophoblast, are identical to CANCER.
This was discovered in 1900 by a brilliant embryologist named Dr John Beard and has subsequently been confirmed in our modern times by Dr. C. Ferretti in the October 2006 issue of Human Reproduction Update, where he states that:
Both cancer and trophoblast cells share the same molecular circuitry for their proliferative, invasive and migratory capacities.
In addition the extraordinary work of Drs Michael J Murray and Bruce A Lessey both from the department of Obstetrics and Gynecology University of North Carolina and their 1999 publication entitled ‘Embryo Implantation and Tumor metastasis: Common Pathways of invasion and Angiogenesis’ present the biology of the trophoblast to the metastatic potential of cancer.
Similarly, both the trophoblast and cancer cells produce produce human Chorionic Gonadotropin (hCG) that doctors use to test for pregnancy.
For years doctors have measured HCG levels in the blood to gauge treatment of certain testicular and ovarian malignancies but never linked the trophoblast and cancer together.
Conclusions and Questions?
Now we have a first clue, that the early placenta or trophoblast is a primitive, highly undifferentiated, highly invasive cellular mass, and proliferates without restraint that contains the same characteristics as an early cancer mass.
You should at this point have several questions “Watson?”
If the trophoblast is indeed cancer that means that every pregnant woman has cancer, so how does the body get rid of the malignancy?
The trophoblast is a result of fertilization of an egg from donated sperm from the male species but cancer can ignite in both male and female without fertilization, how can that be?
How does cancer occur and where does it stem from?
In part 3 all these questions will be answered and the discovery of the origins of cancer over a 100 years ago that was conveniently forgotten.
Edward Cole: [to his doctor] I love the smell of chemo in the morning.
Movie Quote ‘The Bucket List’ 2007
Check out the previous articles in this series
- Bicentennial Voices : The Birth of Chemotherapy ( Yale school of medicine website )
- Madame Curie/History of Radiation Wikipeadia
- Pinopod/Blastocyst/HCG/Zona Pellucida/Syncytiotrophoblast/Chorionic Villi Wikipeadia
- Leukemia Inhibiting factor: roles in embryo implantation and in non hormonal contraception (Scientific World Journal Vol 2014, Article ID 201514 N.Salleh, N.Ginbabu
- Transforming growth factor alph,beta/Platelet derived growth factor/insulin like growth factor/Colony Stimulating factor 1/Interleukin 1,6.10/NF-KB Wikipeadia
- The Trophoblast and the Origins of cancer ( 2009) Nicholas Gonzalez MD,Linda Isaacs MD
- Movie Quote IMDB
My intentions in writing these articles is not to enforce an opinion but simply to present the facts that exist and have existed in history so you can make a judgement or form an opinion.
My only caveat is that I believe that the human organism is so incredibly complex and remarkably intelligent that its creation/evolution is from a divine power,whose intention was to simply keep the body alive with the correct fuel, and if it ran into trouble, be fixed by substances found in nature.
If the body became damaged structurally,chemically or mentally, us humans could acquire the knowledge to repair it using means that work with the body, not against the body.
A truth that was upheld by Hippocrates and a truth upheld by Naturopathic physicians.
A special thank you and tribute to one of the greatest physicians that has lived in our modern era and a great hero of mine Nicholas Gonzalez who wrote with his colleague Dr. Linda Isaacs a ground breaking book ‘The Trophoblast and the Origins of Cancer’ which I am using as part of my research to write these articles on Cancer. In Honor and in Memory to a great man..I salute you Dr Gonzalez.
Author: Eric Malouin